Microsoft Research Releases Quine, a Multimodal World Model System for Biology
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On September 29, 2026, Microsoft Research released Quine, an AI system for biological research. The system includes a biological multimodal world model and an interactive framework connecting scientific tools, literature, and researchers. In a collaboration with the Broad Institute, Quine was applied to pancreatic ductal adenocarcinoma (PDAC) research, used to predict and rank compounds likely to drive tumor cell state transitions. The research team performed wet-lab validation of the top-ranked candidate compounds; reportedly, the process from narrowing down compounds to identifying candidates for validation took only one weekend. No reports from other sources have yet confirmed or supplemented this.
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- Microsoft ResearchSelectedIntroducing Quine: An AI research system designed for the complexity of biology
Microsoft Research launched Quine, a research system combining a multimodal world model of biology with an interactive framework connecting scientific tools, literature, and researchers. With the Broad Institute, it applied the system to pancreatic ductal adenocarcinoma (PDAC) research, predicting and ranking compounds that could drive tumor cell state transitions; wet-lab validation confirmed top-ranked candidates, and narrowing the compound pool to validation candidates took just one weekend.